Scientists develop light-activated bio-glue that could seal fatal wounds in seconds

A new ‘biological glue’ developed by Chinese researchers could one day stop hearts and arteries from uncontrollable bleeding.

Placed on an open wound and activated through UV light, this life-saving sealant rapidly morphs into a non-toxic hydrogel, capable of withstanding both slippery surfaces and the pulsing of heart tissue.

The adhesive sealant hasn’t been tested on human organs just yet, but when a prototype was used inside pigs and rabbits, it performed much better than sutures or other currently available surgical glues.

The proof of concept, the authors say, is best watched in real time. Placed on a gushing liver wound in the video below, the glue can be seen solidifying under UV light until at last, the red eruption is successfully held back. The whole process takes less than half a minute.

“It is the first time that high-pressure bleeding of a beating heart with 6 millimeter diameter cardiac penetration holes was rapidly stopped and the wounds were stably sealed by only using matrix gel within 20 [seconds] without suture,” the authors conclude, adding that while some other similar materials do exist, many also contain harmful chemicals and may require extra sutures afterward.

The new prototype has neither problem. During rabbit surgery, the light-activated gel was able to stop a bleeding liver cut and a femoral artery section in mere seconds.

During pig surgery, it closed up a punctured carotid artery in well under a minute, while also repairing holes in the cardiac wall.

Finely tuned for its purpose, the gel can withstand up to 290 mmHg blood pressure, which is much higher than what most doctors and nurses usually deal with, and far beyond what some other glues can handle.

What’s more, because it is based on the structure of human connective tissue, the extracellular matrix of this glue is compatible with internal organs and arteries, allowing it to bind easier to arterial and cardiac walls.

The result is that all three pigs survived life-threatening heart surgery. Reared for two weeks more, they even showed natural signs of healing with little inflammation to speak of.

“The hydrogel also effectively sealed the heart wound after [two] weeks, and almost no necrosis and very little inflammation were observed at the wound interface in pathology section staining, confirming the excellent biocompatibility of the matrix hydrogel,” the authors report.

While it’s true that pig livers are a similar size to human livers, the team now needs to prove that their findings fully translate to a clinical setting.

Ever hopeful, tissue engineer Hongwei Ouyang — one of the study authors — told ScienceAlert he thinks the product could be ready for human surgical use in the next 3 to 5 years.

The prospect for surgery and emergency situations is tantalizing, and it’s a dream that several companies around the world have been racing towards. For instance, a recently-created ‘elastic’ glue can reportedly seal off a lung or artery wound from air or water in 60 seconds, also using UV light.

In a sense, Ouyang and his colleagues have created a cardiac equivalent: a unique glue that can somehow grab hold of a slippery, beating heart.

This study has been published in Nature Communications.


more recommended stories

  • Epstein had foreign passport to protect him from ‘hijackers’: lawyers

    Jeffrey Epstein, the financier recently charged.

  • Elon Musk’s sister runs passionflix video streaming for romance book movies

    Elon Musk may be the most.

  • The best competing Prime Day 2019 sales — Walmart, Target, eBay, & more

    After four years running, Amazon’s retail.

  • How to set up a custom voicemail greeting on a Galaxy S10

    One of the first things you.

  • I always wanted to be a millionaire and it was nothing like I expected

    Hansson at work. via Basecamp Facebook.

  • Apple AirPod Earbuds Deal: Save $14 to $20 on Amazon Prime Day 2019

    Truly wireless earbuds like Apple’s AirPods.

  • APPLY NOW: Insider Inc. is hiring editorial and video fellows and more

    Insider Inc. has a number of.

  • Video shows men in an over-crowded facility yelling “no shower”

    A video taken and posted on.

  • Sharp and McCann show the future of British boxing is fun and flashy

    02 ARENA, LONDON — Red hot.

  • Jeffrey Epstein launched PR campaign after 2008 sex abuse allegations

    Jeffrey Epstein launched a PR campaign.

  • Prime Day 2019 KitchenAid Stand Mixer deals — sale predictions

    There are some things that never.

  • The best vacuum deals we expect to see during Prime Day 2019

    No matter how diligently you clean.

  • Asylum seeker describes baby’s death from poor medical care in ICE custody

    WASHINGTON (AP) — A Guatemalan mother.

  • A new holding center for migrant children opened in rural Texas

    CARRIZO SPRINGS, Texas (AP) — A.

  • Video seems to show Trump embrace staffer who says he forcibly kissed

    President Donald Trump’s attorneys were accused.

  • How to back up photos from an iPhone with iCloud storage

    If you’re someone who loves taking.

  • Famous people who have flown on Jeffrey Epstein’s private plane

    The financier Jeffrey Epstein, the convicted.

  • 9 questions you should ask flight attendants next time you fly

    Getting on a plane is a.

  • DOJ to swap interpreters with videos at immigration hearings

    The Department of Justice is planning.

  • Federal court ruled against bikini baristas at Washington coffee bars

    Women serving coffee at the Hillbilly.

  • Greece election: Conservative party beats left-wing prime minister

    In his concession speech, Mr Tsipras.

  • Photos of US Navy guided missile destroyer USS Jason Dunham

    During the final days of June,.

  • No-deal Brexit: Boris Johnson to be hit by dozens of new Tory rebels

    LONDON — Dozens more Conservative MPs.

  • Turkey is last major Islamic state not to stand up for China’s Muslims

    In recent months, a wave of.

  • PHOTOS: Sophie Turner’s wedding dress with husband Joe Jonas

    Sophie Turner and Joe Jonas had.

  • The winners and losers of the opening days of NBA free agency

    The NBA offseason has been fast.

  • European stocks are jumping as traders bet on loose Fed policy, while US markets break for the Fourth of July

    Ritzau Scanpix Denmark/Reuters US markets were.

  • Megan Rapinoe shuts down critics: ‘I think I’m extremely American’

    Megan Rapinoe has been no stranger.

  • Steve Irwin and son fed the same crocodile 15 years apart

    Steve Irwin’s 15-year-old son Bob is.

  • Serena Williams will wait before giving Meghan Markle parenting advice

    Serena Williams says she will wait.

  • Stocks are dropping on trade-war jitters after Trump threatens another $4 billion in tariffs on EU goods

    Assoicated Press/Alex Brandon US stocks slid.

  • I went to Times Square to see why tourists love it

    Growing up on Long Island, I.