Overweight teen boys have higher risk of heart muscle damage as adults

(Reuters Health) – Men who were overweight as teens may be more likely to develop a rare type of heart muscle damage that can cause heart failure than men who maintained a healthy weight during adolescence, a Swedish study suggests.

Researchers examined data on height, weight and fitness levels from more than 1.6 million men who enlisted in compulsory military service in Sweden between 1969 and 2005, when they were 18 or 19 years old. At the start, about 10 percent were overweight and about 2 percent were obese.

After a median follow-up of 27 years, 4,477 men developed a disease called cardiomyopathy that makes it harder for the heart to pump blood to the body. This can lead to heart failure.

Compared to men whose weight was right in the middle of a healthy range in adolescence, men who had a healthy weight that was slightly higher during their teen years were 38 percent more likely to develop cardiomyopathy, the study found. Men who were overweight as teens were at least twice as likely to develop this heart muscle damage, and men who were obese had at least five times the risk.

Men who developed cardiomyopathy were about 46 years old on average at the time of their disorder.

“We postulated that the increase in heart failure rates in the young might be due to increasing rates of overweight and obesity,” said senior study author Dr. Annika Rosengren of the Sahlgrenska Academy and the University of Gothenburg in Sweden.

“We were able to demonstrate that there was a very strong link between being obese when young and early heart failure,” Rosengren said by email.

Cardiomyopathy is still rare, and only 0.27 percent of the men were diagnosed with any one of the different forms of this disorder during the study.

People with a body mass index (BMI) below 20, lean but within a healthy weight range, had a low risk of cardiomyopathy, researchers report in Circulation.

However, that risk steadily increased as weight increased, even among men on the high end of what’s considered a healthy weight, with BMIs ranging from 22.5 to 25.

There are several types of cardiomyopathy, but the causes are poorly understood. In one form, called dilated cardiomyopathy, the heart muscle becomes weak and can’t pump blood efficiently. In another, called hypertrophic cardiomyopathy, the heart muscle becomes stiff and the heart can’t fill with blood properly.

In the study, men who were extremely obese with a BMI of 35 and over in their youth were eight times more likely to develop dilated cardiomyopathy as adults compared to men who were lean in their youth. It was not possible to estimate increased risk for hypertrophic cardiomyopathy in men with BMI 35 and above because there were too few cases to provide a meaningful analysis.

The study wasn’t designed to prove whether or how obesity directly causes cardiomyopathy. It’s also not clear if results from this study of predominantly white men would apply to women or to other racial or ethnic groups.

It’s possible that hormonal and metabolic changes in obesity, including high levels of the hormones insulin and leptin, could play a role in causing cardiomyopathy, said Dr. David Ludwig of Harvard Medical School and Boston Children’s Hospital.

“Exposure to high levels of these two hormones, for years or decades, could adversely affect heart muscle structure and function,” Ludwig, who wasn’t involved in the study, said by email. “It’s also possible that other more commonly recognized changes in obesity, such as high blood pressure and high blood sugar, could be involved.”

Broadly speaking, being overweight or obese as a teen and young adult sets people up for more health issues later in life, heart problems included, said Dr. June Tester of the University of California San Francisco Benioff Children’s Hospital Oakland.

“There are some health complications such as cardiomyopathy that evidence has long suggested that some people are simply more `hard-wired’ than others to have risk just because of their genes,” Tester, who wasn’t involved in the study, said by email. “However, this research suggests that the relationship is more complex.”

SOURCE: bit.ly/2ECGyEM Circulation, online May 28, 2019.

Source

more recommended stories

  • Teleflex recalls breathing tubes worldwide after reports of 4 deaths

    (Reuters) – Teleflex Inc said on.

  • In border camps, Syrians rely on doctors in trucks and tents

    AZAZ, Syria (Reuters) – The Syrian.

  • Thailand bans pig imports from Laos after African swine fever outbreak

    BANGKOK (Reuters) – Thailand will ban.

  • FDA approves drug for loss of sexual desire in women

    (Reuters) – The U.S. drug regulator.

  • Missouri orders lone abortion clinic to close; judge keeps it open for now

    ST. LOUIS (Reuters) – Missouri health.

  • Merck CEO sees legal challenge if U.S. adopts drug pricing based on other countries

    NEW YORK (Reuters) – Merck &.

  • Strobing stage lights could up risk of epileptic seizures

    (Reuters Health) – Flashing light effects.

  • Euthanasia law takes effect in Australia’s Victoria state

    MELBOURNE (Reuters) – Voluntary euthanasia became.

  • China to suspend pork imports from third Canadian firm as dispute with Ottawa deepens

    BEIJING (Reuters) – China will block.

  • U.S. records 22 new measles cases, bringing year’s total to 1,044

    (Reuters) – The United States recorded.

  • WHO likely to declare Ebola an international emergency: experts

    GENEVA (Reuters) – The World Health.

  • WHO panel decides not to declare international Ebola emergency

    GENEVA (Reuters) – A World Health.

  • U.S. drugmakers file lawsuit against requiring drug prices in TV ads

    FILE PHOTO: Used blister packets that.

  • Death toll from UK hospital listeria outbreak rises to five

    LONDON (Reuters) – The number of.

  • Female soldiers wanting to suppress periods face barriers

    (Reuters Health) – Military women wanting.

  • Chronic depression after heart attack tied to increased risk of death

    (Reuters Health) – Heart attack survivors.

  • North Korea steps up measures to prevent spread of African swine fever

    SEOUL (Reuters) – North Korea has.

  • Missouri’s only abortion clinic to stay open after injunction issued

    (Reuters) – The only abortion clinic.

  • China to tighten rules on foreigners using genetic material

    FILE PHOTO: A researcher inserts a.

  • Experimental drug delays type 1 diabetes onset in mid-stage trial

    (Reuters Health) – In people at.

  • Abbott device helps in cutting blood sugar in type 2 diabetics: study

    (Reuters) – Insulin-dependent patients with type.

  • USDA investigates unapproved GMO wheat found in Washington state

    CHICAGO (Reuters) – The U.S. Department.

  • As pressure for Afghan peace grows, drug threat remains

    KANDAHAR, Afghanistan (Reuters) – Mohammad Ahmadi,.

  • One in four Ebola cases undetected in Congo: WHO

    GENEVA (Reuters) – Roughly a quarter.

  • U.S. health agency cancels research contract involving use of fetal tissue

    (Reuters) – The Department of Health.

  • Many U.S. kids still eating laundry pods

    Many American children are still being.

  • Nipah virus resurfaces in India’s Kerala after killing 17 last year

    NEW DELHI (Reuters) – The deadly.

  • Therapy in the office: banks take mental health fight in-house

    LONDON (Reuters) – In ‘Billions’, a.

  • Lynparza stalls pancreatic cancer in patients with BRCA mutations: study

    CHICAGO (Reuters) – AstraZeneca and Merck.

  • Novartis hopes Kisqali data will help narrow gap to blockbuster rival

    ZURICH (Reuters) – Novartis has released.

  • Missouri abortion clinic to stay open for now after court order

    ST. LOUIS (Reuters) – Missouri’s only.

  • South Korea braces for African swine fever outbreak after North Korea case

    SEOUL (Reuters) – South Korea readied.