Jurgen Klopp’s side romped to the title last season, depriving City of winning the league three times in a row.
After watching Liverpool win their opening pair of league fixtures, City responded in perfect manner by sweeping aside Wolves 3-1 at Molineux.
In a virtuoso first-half display, goals from De Bruyne and Phil Foden set Pep Guardiola’s side on the way.
They had to withstand intense pressure from the hosts in the second half, but sealed the win in the closing stages.
And speaking after the game, De Bruyne has revealed his teammates knew they had to get off to a fast start to stand a chance.
He told the club’s official site: “If the title pace is (the) same as the last few years it’ll be hard. We want to fight with Liverpool. That’s what sport is all about.
“With just two weeks training, it was always going to be hard. But we kept it tight and I think we did really well and we know you have to start well.
“Wolves have been a bogey team for us, so to come here and do this performance is good.
“We were missing some players. We will go game by game, Thursday (in the Carabao Cup against Bournemouth ) is another one.”
Foden shone as Man City embark on their first campaign without Spanish star David Silva and De Bruyne is confident they have enough attacking options to cause any team problems.
“Everyone has to play with their own quality,” he added. David is the master of tight spaces, but in Phil, Bernardo (Silva), Riyad (Marhez) and Raheem (Sterling), we have players who can do the job. But obviously he is a big miss.
“We have so many attacking players, I can slot them in and they can do the rest depending on the formation of our opponents.”