Premier League clubs have been warned that squad outbreaks of Covid-19 will not result in postponed matches this season.
Authorities are determined to get the already delayed campaign finished on time which has seen a fixture pile up.
And clubs have been told that, unless they have less than 14 players available, requests to postpone games will be rejected.
They will also be expected to tap into their U21 squads to ensure that they fulfill their fixtures.
It has been made clear to clubs in guidance sent out by the Premier League that any player who has played even a minute of first-team football will be seen as an option should their squads become depleted due to the illness, reports the Daily Mail.
The Premier League is yet to release the results of the pre-season testing that has been undertaken, but there are fears of an outbreak.
A host of positive tests were returned last month after players went off around the globe to enjoy their summer holidays.
A total of 14 players across 12 clubs were found to have contracted coronavirus.
That had put the upcoming opening weekend of the season at risk, but the Premier League have set an extremely high bar for postponing games.
Authorities will also show no sympathy if a squad is suffering because individuals have breached Covid-19 protocols or are undertaking a period of mandatory isolation after an overseas trip.
The Premier League have a contractual obligation to get the 2020/21 season finished on time which has led to their strict approach.
Any team who fails to play their scheduled fixtures will have to face an independent disciplinary panel.
Leiniency is set to be a short supply however with the Premier League ready to hand out fines or even points deductions for repeat offenders.